A recent small scale study of synthetic resveratrol by DSM done on mice, indicated a possible improvement in the animals’ memory. Biotivia has gone an important step further in a human trial done at Northumbria University on brain blood flow, in which it was shown that their Bioforte all-natural resveratrol improved this brain function in humans. Biotivia has been the leading provider of resveratrol for health studies on both animals and humans for the past five years.
Synthetic versions of resveratrol are made in China and India using either organic chemistry, a process in which a target molecule is created from a broth of chemicals, or by fermentation, an often problematical system in which genetically modified (GMO) bacteria or yeast are made to create the molecule. Both methods often leave significant amounts of unknown contaminants in the resveratrol. This is why Biotivia uses natural resveratrol produced from the wild organic polygonum cuspidatum plant to produce its proprietary resveratrol.
Synthetic versions of resveratrol are made in China and India using either organic chemistry, a process in which a target molecule is created from a broth of chemicals, or by fermentation, an often problematical system in which genetically modified (GMO) bacteria or yeast are made to create the molecule. Both methods often leave significant amounts of unknown contaminants in the resveratrol. This is why Biotivia uses natural resveratrol produced from the wild organic polygonum cuspidatum plant to produce its proprietary resveratrol.
Biotivia’s Managing Director, James Betz stated recently, We do not believe that the risks of using GMO derived synthetic resveratrol in our supplements is warranted simply by the obvious economic advantages of this material. Our research partners are in agreement with this decision.” The drawbacks of synthetic versions of natural compounds were highlighted recently when a trial of Glaxo Smith Kline’s analog of resveratrol called SRT 501 was halted due to “unexpected safety concerns”. No toxicity has been observed in natural resveratrol over hundreds of animal and human trials during the past 20 years. The proven purity, safety and lack of toxicity of natural resveratrol means that Biotivia’s supplements may be safely used not only in animal trials, but in human trials as well, such as the one at Northumbria and many others in which Biotivia’s resveratrol has been shown to produce impressive health benefits. This is important because clinical trials done on animals, especially on parameters such as memory and cognition, have very limited value in terms of their applicability to humans.
The Northumbria human clinical trial on university students showed that strong improvements in the human subjects’ brain blood flow resulted from oral administration of Bioforte resveratrol. The brain’s ability to solve problems, create new ideas and simply to think and reason requires a healthy level of cerebral blood flow. A deficiency of which is a cause of debilitating strokes and other brain damage and can result in dementia and impaired motor skills and cognition.
Cerebral blood flow dramatically increased
In the double blind, peer-reviewed, published study at the University of Northumbria, UK, a dose of either 250mg or 500mg of Resveratrol was shown to increase cerebral blood flow by just over 100% to 200% respectively in 22 university student subjects. Another study performed by Scientists at the University of Missouri-Columbia recently found that Resveratrol may also lessen brain damage from strokes.
The Northumbria human clinical trial on university students showed that strong improvements in the human subjects’ brain blood flow resulted from oral administration of Bioforte resveratrol. The brain’s ability to solve problems, create new ideas and simply to think and reason requires a healthy level of cerebral blood flow. A deficiency of which is a cause of debilitating strokes and other brain damage and can result in dementia and impaired motor skills and cognition.
Cerebral blood flow dramatically increased
In the double blind, peer-reviewed, published study at the University of Northumbria, UK, a dose of either 250mg or 500mg of Resveratrol was shown to increase cerebral blood flow by just over 100% to 200% respectively in 22 university student subjects. Another study performed by Scientists at the University of Missouri-Columbia recently found that Resveratrol may also lessen brain damage from strokes.
In the Northumbria University study, the students were given either one or two 250mg capsules of a supplement called Bioforte Resveratrol approximately 45 minutes before taking a mental test which required them to rapidly solve simple math problems presented on a computer.
Both Resveratrol doses resulted in increased cerebral blood flow during mental tasks, and was measured by the total concentration of cerebral deoxyhemoglobin after the students were given Resveratrol, which suggests enhanced oxygen extraction.
The increase was noticeable toward the end of the 45-min absorption phase and throughout the task performance phase. The control group of students who were not given Resveratrol showed no difference in brain blood flow or problem solving ability. These results appear to confirm that single doses of Resveratrol taken orally can increase cerebral blood flow in human subjects.
Could Resveratrol help increase cognition on demand?
“It is very interesting to note,” states James Betz PhD, managing director of Biotivia, the company whose Resveratrol was used in the study, “that the increase in blood flow occurred essentially “on demand”. That is, when the students were not concentrating on the math problems, blood flow was slightly above normal … but as soon as they were called upon to solve the problems, blood flow increased substantially.”
“It is very interesting to note,” states James Betz PhD, managing director of Biotivia, the company whose Resveratrol was used in the study, “that the increase in blood flow occurred essentially “on demand”. That is, when the students were not concentrating on the math problems, blood flow was slightly above normal … but as soon as they were called upon to solve the problems, blood flow increased substantially.”
Betz continued: “It’s essentially just-in-time mental agility, with important ramifications for students, business people, or anybody who needs a mental boost from time to time to help deal with a particularly challenging task.” This study, as well as a growing number of in vitro and human clinical trials at the National Institute of Health, and at university medical schools and research organizations in the US and Europe, illustrates the remarkable range of potential health benefits of the Resveratrol molecule both for the prevention and treatment of a wide range of medical conditions.
Biotivia Resveratrol is also being used in studies currently underway at the Albert Einstein Medical Center, New York, investigating Resveratrol’s potential neuro-protective properties as a possible therapeutic aid to Alzheimer and dementia sufferers. Another university research project is investigating Biotivia’s Bioforte Resveratrol potential to increase insulin sensitivity in diabetes and metabolic syndrome patients.
Biotivia recently announced a collaboration with the University of Ferrara ThalLab on human clinical trials of Resveratrol for the treatment of Thalassemia at two hospitals in Italy and one large medical center in Egypt.
About Biotivia Bioceuticals
Biotivia was established in 1992 in Vienna, Austria as a supplier of natural raw materials and botanicals to the supplement and functional food industries, and to researchers and scientific institutions worldwide. The company has a range of unique Resveratrol-based formulations for consumers at www.biotivia.com.
About Northumbria University Northumbria University, in Newcastle upon Tyne, is an expanding multicultural learning community, with excellent links with further and higher education, industry and commerce throughout the UK, Europe and beyond.
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