Friday, June 11, 2010

Traumatic Brain Injury Could Also Mean Poor Sleep

 Traumatic Brain Injury Could Also Mean Poor Sleep
Traumatic brain injury could also mean poor sleep, say Australian researchers.

Scientists with the Monash University's School of Psychology and Psychiatry measured in a laboratory setting the sleep of 23 patients with Traumatic Brain Injury (TBI) with 23 healthy people who had not suffered trauma.

Study leader, Associate Professor Shantha Rajaratnam said patients with TBI showed increased sleep disturbance and reported poorer sleep quality, and higher anxiety and depressive symptoms than healthy volunteers.

"These results suggest that TBI may disrupt the brain structures that regulate sleep, including the production of melatonin. Patients with TBI showed decreased sleep efficiency and increased periods of being awake after trying to sleep," Associate Professor Rajaratnam said.

Study co-author, Professor Jennie Ponsford, said injury-related damage to sleep-wake regulating centres and associated pathways or neurotransmitter systems was the most likely cause of such disturbances.

The study also revealed that TBI patients spent more time in a stage of sleep called slow wave sleep or deep sleep (after controlling for anxiety and depression). They were also awake more after initially falling asleep, averaging 62 minutes per night awake compared to 27 minutes for the healthy group.

The study also revealed that patients with TBI had significantly lower levels of evening melatonin production. Melatonin is a hormone produced by the pineal gland in the brain, and is known to be involved in the regulation of sleep.

The results suggest that there are at least two factors contributing to sleep disturbances in patients with TBI. Elevated depression is associated with reduced sleep quality, and increased slow wave sleep is attributed to the effects of mechanical brain damage.

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